Spatio-Temporal Distribution of Mycobacterium tuberculosis Complex Strains in Ghana
Identifieur interne : 000142 ( Main/Exploration ); précédent : 000141; suivant : 000143Spatio-Temporal Distribution of Mycobacterium tuberculosis Complex Strains in Ghana
Auteurs : Dorothy Yeboah-Manu [Ghana] ; P. Asare [Ghana] ; A. Asante-Poku [Ghana] ; I. D. Otchere [Ghana] ; S. Osei-Wusu [Ghana] ; E. Danso [Ghana] ; A. Forson [Ghana] ; K. A. Koram [Ghana] ; Sebastien Gagneux [Suisse]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
There is a perception that genomic differences in the species/lineages of the nine species making the
Mycobacterial species isolated by culture from consecutively recruited pulmonary tuberculosis patients presenting at selected district/sub-district health facilities were confirmed as MTBC by IS
Among 2,551 isolates, 2,019 (79.1%), 516 (20.2%) and 16 (0.6%) were identified as
This study demonstrated that overall, 79.1% of TB in Ghana is caused by MTBss and 20% by
Url:
DOI: 10.1371/journal.pone.0161892
PubMed: 27564240
PubMed Central: 5001706
Affiliations:
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Asare</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Asante Poku, A" sort="Asante Poku, A" uniqKey="Asante Poku A" first="A." last="Asante-Poku">A. Asante-Poku</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Otchere, I D" sort="Otchere, I D" uniqKey="Otchere I" first="I. D." last="Otchere">I. D. Otchere</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Osei Wusu, S" sort="Osei Wusu, S" uniqKey="Osei Wusu S" first="S." last="Osei-Wusu">S. Osei-Wusu</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Danso, E" sort="Danso, E" uniqKey="Danso E" first="E." last="Danso">E. Danso</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Forson, A" sort="Forson, A" uniqKey="Forson A" first="A." last="Forson">A. Forson</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Chest Diseases, Korle-Bu Teaching Hospital, Korle-bu, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Chest Diseases, Korle-Bu Teaching Hospital, Korle-bu, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Koram, K A" sort="Koram, K A" uniqKey="Koram K" first="K. A." last="Koram">K. A. Koram</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Gagneux, Sebastien" sort="Gagneux, Sebastien" uniqKey="Gagneux S" first="Sebastien" last="Gagneux">Sebastien Gagneux</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>University of Basel, Basel, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>There is a perception that genomic differences in the species/lineages of the nine species making the <italic>Mycobacterium tuberculosis</italic> complex (MTBC) may affect the efficacy of distinct control tools in certain geographical areas. We therefore analyzed the prevalence and spatial distribution of MTBC species and lineages among isolates from pulmonary TB cases over an 8-year period, 2007–2014.</p></sec><sec id="sec002"><title>Methodology</title><p>Mycobacterial species isolated by culture from consecutively recruited pulmonary tuberculosis patients presenting at selected district/sub-district health facilities were confirmed as MTBC by IS<italic>6110</italic> and rpo<italic>ß</italic> PCR and further assigned lineages and sub lineages by spoligotyping and large sequence polymorphism PCR (RDs 4, 9, 12, 702, 711) assays. Patient characteristics, residency, and risks were obtained with a structured questionnaire. We used SaTScan and ArcMap analyses to identify significantly clustered MTBC lineages within selected districts and spatial display, respectively.</p></sec><sec id="sec003"><title>Results</title><p>Among 2,551 isolates, 2,019 (79.1%), 516 (20.2%) and 16 (0.6%) were identified as <italic>M</italic>. <italic>tuberculosis</italic> sensu stricto (MTBss), <italic>M</italic>. <italic>africanum</italic> (Maf), 15 <italic>M</italic>. <italic>bovis</italic> and 1 <italic>M</italic>. <italic>caprae</italic>, respectively. The proportions of MTBss and Maf were fairly constant within the study period. Maf spoligotypes were dominated by Spoligotype International Type (SIT) 331 (25.42%), SIT 326 (15.25%) and SIT 181 (14.12%). We found <italic>M</italic>. <italic>bovis</italic> to be significantly higher in Northern Ghana (1.9% of 212) than Southern Ghana (0.5% of 2339) (p = 0.020). Using the purely spatial and space-time analysis, seven significant MTBC lineage clusters (p< 0.05) were identified. Notable among the clusters were Ghana and Cameroon sub-lineages found to be associated with north and south, respectively.</p></sec><sec id="sec004"><title>Conclusion</title><p>This study demonstrated that overall, 79.1% of TB in Ghana is caused by MTBss and 20% by <italic>M</italic>. <italic>africanum</italic>. Unlike some West African Countries, we did not observe a decline of Maf prevalence in Ghana.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brosch, R" uniqKey="Brosch R">R Brosch</name></author><author><name sortKey="Gordon, Sv" uniqKey="Gordon S">SV Gordon</name></author><author><name sortKey="Marmiesse, M" uniqKey="Marmiesse M">M Marmiesse</name></author><author><name sortKey="Brodin, P" uniqKey="Brodin P">P Brodin</name></author><author><name sortKey="Buchrieser, C" uniqKey="Buchrieser C">C Buchrieser</name></author><author><name sortKey="Eiglmeier, K" uniqKey="Eiglmeier K">K Eiglmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagneux, S" uniqKey="Gagneux S">S Gagneux</name></author><author><name sortKey="Small, Pm" uniqKey="Small P">PM Small</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wells, Aq" uniqKey="Wells 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P" uniqKey="Caulley P">P Caulley</name></author><author><name sortKey="Minamikawa, M" uniqKey="Minamikawa M">M Minamikawa</name></author><author><name sortKey="Bonsu, F" uniqKey="Bonsu F">F Bonsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goyal, M" uniqKey="Goyal M">M Goyal</name></author><author><name sortKey="Lawn, S" uniqKey="Lawn S">S Lawn</name></author><author><name sortKey="Afful, B" uniqKey="Afful B">B Afful</name></author><author><name sortKey="Acheampong, Jw" uniqKey="Acheampong J">JW Acheampong</name></author><author><name sortKey="Griffin, G" uniqKey="Griffin G">G Griffin</name></author><author><name sortKey="Shaw, R" uniqKey="Shaw R">R Shaw</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Ghana</li><li>Suisse</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Yeboah Manu, Dorothy" sort="Yeboah Manu, Dorothy" uniqKey="Yeboah Manu D" first="Dorothy" last="Yeboah-Manu">Dorothy Yeboah-Manu</name></region><name sortKey="Asante Poku, A" sort="Asante Poku, A" uniqKey="Asante Poku A" first="A." last="Asante-Poku">A. Asante-Poku</name><name sortKey="Asare, P" sort="Asare, P" uniqKey="Asare P" first="P." last="Asare">P. Asare</name><name sortKey="Danso, E" sort="Danso, E" uniqKey="Danso E" first="E." last="Danso">E. Danso</name><name sortKey="Forson, A" sort="Forson, A" uniqKey="Forson A" first="A." last="Forson">A. Forson</name><name sortKey="Koram, K A" sort="Koram, K A" uniqKey="Koram K" first="K. A." last="Koram">K. A. Koram</name><name sortKey="Osei Wusu, S" sort="Osei Wusu, S" uniqKey="Osei Wusu S" first="S." last="Osei-Wusu">S. Osei-Wusu</name><name sortKey="Otchere, I D" sort="Otchere, I D" uniqKey="Otchere I" first="I. D." last="Otchere">I. D. Otchere</name></country><country name="Suisse"><noRegion><name sortKey="Gagneux, Sebastien" sort="Gagneux, Sebastien" uniqKey="Gagneux S" first="Sebastien" last="Gagneux">Sebastien Gagneux</name></noRegion><name sortKey="Gagneux, Sebastien" sort="Gagneux, Sebastien" uniqKey="Gagneux S" first="Sebastien" last="Gagneux">Sebastien Gagneux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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